Scientific interests:
Effect of compounds of natural origin (flavonoids, coumarins) on the induction of programmed death in human cancer cells. Analysis of the molecular mechanisms leading to the elimination of transformed cells by apoptosis or autophagy.
Professional skills:
Cell biology research: distinguishing types of programmed death, cell migration, immunocytochemistry, commet assay, cell culture, light and fluorescence microscopy, flow cytometry
Molecular biology research: electrophoresis of proteins and nucleic acids (denatured and native conditions), immunoblotting, silencing of gene expression using oligonucleotides and siRNA, PCR, immunoprecipitation
Classes:
Human anatomy, Histology with elements of human anatomy, Embryology and animal histology, Molecular mechanisms of action of selected groups of drugs, Neurophysiology, Basics of genetics and pathology of development, Elements of pathophysiology
Recent papers:
Sumorek-Wiadro J, Zając A, Maciejczyk A, Jakubowicz-Gil J. Furanocoumarins in anticancer therapy - For and against. Fitoterapia. 2020, 142:104492. doi: 10.1016/j.fitote.2020.104492.
Sumorek-Wiadro J, Zając A, Langner E, Skalicka-Woźniak K, Maciejczyk A, Rzeski W, Jakubowicz-Gil J. Antiglioma Potential of Coumarins Combined with Sorafenib. Molecules. 2020, 25(21):5192. doi: 10.3390/molecules25215192.
Sumorek-Wiadro J, Zając A, Bądziul D, Langner E, Skalicka-Woźniak K, Maciejczyk A, Wertel I, Rzeski W, Jakubowicz-Gil J. Coumarins modulate the anti-glioma properties of temozolomide. Eur J Pharmacol. 2020, 881:173207. doi: 10.1016/j.ejphar.2020.173207.
Sugier P, Jakubowicz-Gil J, Sugier D, Kowalski R, Gawlik-Dziki U, Kołodziej B, Dziki D. Chemical Characteristics and Anticancer Activity of Essential Oil from Arnica Montana L. Rhizomes and Roots. Molecules. 2020, 25(6):1284. doi: 10.3390/molecules25061284.
Bądziul D, Jakubczyk P, Chotorlishvili L, Toklikishvilie Z, Traciak J, Jakubowicz-Gil J, Chmiel-Szajner S. Mathematical Prostate Cancer Evolution: Effect of Immunotherapy Based on Controlled Vaccination Strategy. Comput Math Methods Med. 2020, 2020:7970265. doi: 10.1155/2020/7970265.
Hułas-Stasiak M, Jakubowicz-Gil J, Dobrowolski P, Grzesiak M, Muszyński S, Świątkiewicz M, Tomaszewska E. Regulation of folliculogenesis by growth factors in piglet ovary exposed prenatally to β-hydroxy-β-methylbutyrate (HMB). Ann Anim Sci. 2020, 20(3):899–917. DOI: 10.2478/aoas-2020-0026.
Sugier D, Sugier P, Jakubowicz-Gil J, Winiarczyk K, Kowalski R. Essential Oil from Arnica Montana L. Achenes: Chemical Characteristics and Anticancer Activity. Molecules. 2019, 24(22):4158. doi: 10.3390/molecules24224158.
Hułas-Stasiak M, Jakubowicz-Gil J, Dobrowolski P, Tomaszewska E, Muszyński S. Maternal β-hydroxy-β-methylbutyrate (HMB) supplementation during pregnancy affects early folliculogenesis in the ovary of newborn piglets.Theriogenology. 2019, 128:91-100. doi: 10.1016/j.theriogenology.2019.02.003.
Kozioł E, Luca SV, Marcourt L, Nour M, Hnawia E, Jakubowicz-Gil J, Paduch R, Mroczek T, Wolfender J-L, Skalicka-Woźniak K. Efficient extraction and isolation of skimmianine from New Caledonian Plant Medicosmaleratii and evaluation of its effects on apoptosis, necrosis, and autophagy. Phytochem Lett. 2019, 30:224-230
Jakubowicz-Gil J, Bądziul D, Langner E, Wertel I, Zając A, Rzeski W. Temozolomide and sorafenib as programmed cell death inducers of human glioma cells. Pharmacol Rep. 2017, 69(4):779-787. doi: 10.1016/j.pharep.2017.03.008.
Jakubowicz-Gil J, Paduch R, Skalicka-Woźniak K, Sumorek-Wiadro J, Zając A, Gawron A. Hsps responsible for apoptosis induction failure in cervical cancer cells upon osthole and tamoxifen treatment. Post Hig Med Dośw. 2019, 73:563-571.
