Studies in the areas:

• solid state chemistry, X-ray crystallography, crystal engineering, supramolecular chemistry, coordination chemistry

Research topics:

• synthesis and structural studies of new crystal forms (polymorphs, solvates) of biologically active compounds,
• mechanochemical synthesis, structural and physicochemical studies of pharmaceutical co-crystals,
• synthesis, structural and physicochemical studies of Cu(II) and Zn(II) complexes with biologically active compounds (potential antibacterial and anticancer drugs)

Research methods:

• Single crystal and powder X-ray diffraction
• Infrared spectroscopy (ATR-FTIR)
• Thermal analysis (TG/DSC)

Scientific achievements:

• 73 papers, 2 patents (PL), 115 conference reports  

Collaboration:

• University of Warsaw, Poland
• University of Cambridge, UK
• University College London, UK
• University of Montpellier, France
• Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Poland
• Faculty of Pharmacy, Medical University in Lublin, Poland

 Grants:

• 'Polymorphism of molecular complexes of 2-pyridinecarboxaldehyde N¹-benzoylhydrazone with aliphatic dicarboxylic acids', 03.11.2018 - 02.11.2019, NCN, MINIATURA2, No. 2018/02/X/ST5/01417, Principal investigator
• 'Structural and electronic properties as well as biological activity of the Fe, Cu and Zn complexes with selected hydrazones and amidrazones', 27-10.2010 - 26.10.2013, MNiSW/NCN, No. N N204 546839, Principal investigator
• 'New safe for man and natural environment antibacterial compounds obtained from the apple extracts of the speciec Gold Milenium ans Melfree. Physicochemical and microbiological studies',19.03.2010 - 18.03.2013, MNiSW/NCN, No. N N305 384538, Co-investigator
• 'Combined neutron and X-ray single crystal diffraction studies of selected 2-pyridinecarboxaldehyde hydrazones and their derivatives, 9-11.03.2012, Neutron diffraction measurement grant, RB 1210192, Rutherford-Appleton Laboratory, ISIS, Oxford, UK, Principal investigator

Selected papers:

1. A. Trimdale-Deksne, A. Kons, L. Orola, A. Mishnev, D. Stepanovs, L. Mazur, M. Skiba, M. K. Dudek, N. Fantozzi, D. Virieux, E. Colacino, A. Be̅rziņš, Crystallographic and Computational Analysis of the Solid-Form Landscape of Three Structurally Related Imidazolidine-2,4-dione Active Pharmaceutical Ingredients: Nitrofurantoin, Furazidin, and Dantrolene. Cryst. Growth Des. 2023, 23(2), 930-945. DOI: 10.1021/acs.cgd.2c01142

2. J. Fedorowicz, C. D. Cruz, M. Morawska, K. Ciura, S. Gilbert-Girard, L. Mazur, H. Mäkkylä, P. Ilina, K. Savijoki, A. Fallarero, P. Tammela, J. Sączewski, Antibacterial and antibiofilm activity of permanently ionized quaternary ammonium fluoroquinolones, Eur. J. Med. Chem. 2023, 254, 115373. DOI: 10.1016/j.ejmech.2023.115373.

3. R. Paprocka, L.  Pazderski, L. Mazur, M. Wiese-Szadkowska, J. Kutkowska, M. Nowak, A. Helmin-Basa, Synthesis and structural study of amidrazone derived pyrrole-2,5-dione derivatives: potential anti-inflammatory agents. Molecules, 2022, 27(9), 2891. DOI:10.3390/molecules27092891

4. M. Kalinowska, E. Gołębiewska, L. Mazur, H. Lewandowska, M. Pruszyński, G. Świderski, M. Wyrwas, N. Pawluczuk, W. Lewandowski, Crystal structur, spectroscopic characterization, antioxidant and cytotoxic activity of new Mg(II) and Mn(II)/Na(I) complexes of isoferulic acid. Materials, 2021, 14(12), 3236. DOI: 10.3390/ma14123236

5. L. Mazur, I. Materek, A. D. Bond, W. Jones, Multicomponent crystal forms of a biologically active hydrazones with some dicarboxylic acids: Salts or cocrystals? Cryst. Growth Des. 2019, 19, 2663-2678, DOI: 10.1021/acs.cgd.8b01795

6. L. Mazur, J. Sączewski, K. N. Jarzembska, K. Szwarc-Karabyka, R. Paprocka, B. Modzelewska-Banachiewicz, Synthesis, structural characterization and reactivity of new trisubstituted N¹-acylamidrazones: solid state and solution studies. CrystEngComm, 2018, 20, 4179-4193, DOI: 10.1039/c8ce00701b 

7. R. Paprocka, M. Wiese-Szadkowska, A. Helmin-Basa, L. Mazur, J. Kutkowska, J. Michałkiewicz, B. Modzelewska-Banachiewicz, Synthesis and evaluation of new amidrazone-derived hydrazides as a potential anti-inflammatory agent. Monatsh. Chem. 2018, 149, 1493-1500, DOI: 10.1007/s00706-018-2197-8  

8. R. Łyszczek, H. Głuchowska, L. Mazur, B. Tarasiuk, V. Kinzhybalo, A. Kirillov, Structural diversity of alkali metal coordination polymers driven by flexible biphenyl-4,4’-dioxydiacetic acid. J. Solid State Chemistry, 2018, 265, 92-99, DOI: 10.1016/j.jssc.2018.05.022

9. M. Kalinowska, L. Mazur, A. Jabłońska-Trypuć, W. Lewandowski, A new calcium 2,5-dihydroxybenzoate: Synthesis, characterization and antioxidant studies and stress mediated cytotoxity in MCF-7 cells. J. Saudi. Chem. Soc. 2018, 22, 742-756, DOI: 10.1016/j.jscs.2017.12.006

10. L. Mazur, A. E. Kozioł, K. N. Jarzembska, R. Paprocka, B. Modzelewska-Banachiewicz, Polymorphism and isostructurality of the series of 3-(4,5-diaryl-4H-1,2,4-triazole-3-yl)propenoic acid derivatives. Cryst. Growth Des. 2017, 17, 2104-2115, DOI: 10.1021/acs.cgd.7b00080

11. J. Sienkiewicz-Gromiuk, B. Tarasiuk, L. Mazur, New organic single crystal of (benzylthio)acetic acid: Synthesis, crystal structure, spectroscopic (ATR-FTIR, 1H and 13C NMR) and thermal characterization. J. Mol. Struct. 2016, 1110, 65-71, DOI: 10.1016/j.molstruc.2016.01.016

12. L. Mazur, K. Jarzembska, R. Kamiński, A. A. Hoser, A. Ø. Madsen, E. Pindelska, M. Zielińska-Pisklak, Crystal structures and thermodynamic properties of polymorphs and hydrates of selected 2-pyridine-carboxaldehyde hydrazones. Cryst. Growth Des. 2016, 16, 3102-3112, DOI: 10.1016/j.molstruc.2016.01.016

13. M. Kalinowska, L. Mazur, E. Rogulska, A. Korczak, G. Świderski, W. Lewandowski: Calcium complex of 2,5-dihydroxybenzoic acid (gentisic acid), Synthesis, crystal structure and spectroscopic properties. J. Coord. Chem. 2016, 69(16), 2415-2421, DOI: 10.1080/00958972.2016.1197389

14. O. Demchuk, K. Kapłon, L. Mazur, D. Strzelecka, K. M. Pietrusiewicz, Readily available catalysts for demanding Suzuki-Miyaura coupling under mild conditions. Tetrahedron, 2016, 72(42), 6668-6677, DOI: 10.1016/j.tet.2016.08.087

15. L. Mazur, K. Jarzembska, R. Kamiński, K. Wozniak, E. Pindelska, M. Zielińska-Pisklak, Substituent and solvent effects on intermolecular interactions in crystals of N-acylhydrazone derivatives: single-crystal X-ray, solid-state NMR and computational studies. Cryst. Growth Des. 2014, 14, 2263-2281, DOI: 10.1021/cg401866x

16. A. Ostasz, R. Łyszczek, L. Mazur, B. Tarasiuk, Co-crystal formation between 2-amino-4,6-dimethyl-pyrimidine and new p-xylylene-bis(thioacetic) acid. CrystEngComm, 2014, 16, 10262-10272, DOI: 10.1039/c4ce01567c