Moje zainteresowania oraz działalność naukowa dotyczą spektroskopii i mikroskopii molekularnej w zastosowaniu do badań biofizycznych.

Jestem autorem m.in. następujących publikacji naukowych:

1. Raut, S., Rich, R., Fudala, R., Butler, S., Kokate, R., Gryczynski, Z., Luchowski, R., Gryczynski, I.; Resonance energy transfer between fluorescent BSA protected Au nanoclusters and organic fluorophores. Nanoscale, 2014, 6, 385-391, 10.1039/c3nr03886f.
2. Starzyk, J., Gruszecki, M., Tutaj, K., Luchowski, R., Szlazak, R., Wasko, P., Grudzinski, W., Czub, J., Gruszecki, W.I.; Self-Association of Amphotericin B: Spontaneous Formation of Molecular Structures Responsible for the Toxic Side Effects of the Antibiotic. J. Phys. Chem. B, 2014, 118, 13821-13832, 10.1021/jp510245n
3. Janik E., Bednarska J., Zubik M., Sowinski K., Luchowski R., Grudzinski W., Gruszecki W.I.; Is It Beneficial for the Major Photosynthetic Antenna Complex of Plants To Form Trimers? J Phys Chem B. 2015, 119(27), 8501–8508.
4. Tutaj K., Szlazak R., Starzyk J., Wasko P., Grudzinski W., Gruszecki W.I., Luchowski R.; The orientation of the transition dipole moments of a polyene antibiotic Amphotericin B under UV-VIS studies. J Photochem Photobiol B-Biol. 2015, 151, 83–88.
5. Gruszecki W.I., Kulik A.J., Janik E., Bednarska J., Luchowski R., Grudzinski W., Dietler G.; Nanoscale resolution in infrared imaging of protein-containing lipid membranes. Nanoscale. 2015, 7(35), 14659–14662.
6. Gruszecki W.I., Luchowski R., Zubik M., Grudzinski W.; Photothermal Microscopy: Imaging of Energy Dissipation From Photosynthetic Complexes. Anal Chem. 2015, 87(19), 9572–9575.
7. Janik, E., Bednarska, J., Zubik, M., Sowinski, K., Luchowski, R., Grudzinski, W., Matosiuk, D., Gruszecki, W.I.; The xanthophyll cycle pigments, violaxanthin and zeaxanthin, modulate molecular organization of the photosynthetic antenna complex LHCII. Arch Biochem Biophys. 2016, 592, 1-9
8. Tutaj, K., Szlazak, R., Szalapata, K., Starzyk, J., Luchowski, R., Grudzinski, W., Osinska-Jaroszuk, M., Jarosz-Wilkolazka, A., Szuster-Ciesielska, A.,  Gruszecki, W.I.; Amphotericin B-silver hybrid nanoparticles: synthesis, properties and antifungal activity. Nanomedicine : nanotechnology, biology, and medicine. 2016, 12(4), 1095-1103, DOI:10.1016/j.nano.2015.12.378.
9. Palusinska-Szysz, M., Zdybicka-Barabas, A., Reszczynska, E., Luchowski, R., Kania, M., Gisch, N., Waldow, F., Mak, P., Danikiewicz, W., Gruszecki, W.I. Cytrynska, M.; The lipid composition of Legionella dumoffii membrane modulates the interaction with Galleria mellonella apolipophorin III. Biochimica et Biophysica Acta. 2016, 1861, 617–629.
10. Grudzinski, W., Janik, E., Bednarska, J., Welc, R., Zubik, M., Sowinski, K., Luchowski, R., Gruszecki, W.I.; Light-driven reconfiguration of a xanthophyll violaxanthin in the photosynthetic pigment−protein complex LHCII: A resonance Raman study. J Phys Chem B. 2016, 19, 4373-4382.
11. Grudzinski, W., Krzeminska, I.; Luchowski, R., Nosalewicz, A., Gruszecki, W.I.; Strong-light-induced yellowing of green microalgae Chlorella: A study on molecular mechanisms of the acclimation response. Algal Research Biomass, Biofuels and Bioproducts. 2016, 16, 245-254. DOI: 10.1016/j.algal.2016.03.021
12. Grudzinski, W., Sagan, J.; Welc, J.; Luchowski, R., Gruszecki, W.I.; Molecular organization, localization and orientation of antifungal antibiotic Amphotericin B in a single lipid bilayer. Scientific Reports. 2016, 6, 32780. DOI: 10.1038/srep32780
13. Welc, R., Luchowski, R., Grudzinski, W., Puzio, M., Sowinski, K., Gruszecki, W.I.; A key role of xantophylls that are not embedded in proteins in regulation of the photosynthetic antenna function in plants, reveald by monomolecular layer studies. J Phys Chem B. 2016, DOI: 10.1021/acs.jpcb.6b10393
14. Janik, E., Bednarska, J., Zubik, M., Luchowski, R., Mazur, R., Sowinski, K., Grudzinski, W., Garstka, M., Gruszecki, W.I.; A chloroplast „wake up” mechanism: Illumination with weak light activates the photosynthetic antenna function in dark-adapted plants. J Plant Physiology. 2017, 210, 1–8.
15. Janik, E., Bednarska J., Sowinski K., Luchowski R., Zubik M., Grudzinski W., Gruszecki W.I.; Light-Induced Formation of Dimeric LHCII. Photosynthesis Research 2017, 132, 265–76. doi:10.1007/s11120-017-0387-6.
16. Drozdziel, A., Turek, M., Pyszniak, K., Prucnal, S., Luchowski, R., Grudzinski, W., Klimek-Turek, A., Partyka, J.; Modification of Optical and Electrical Properties of PET Foils by He+, Ne+ and Ar+ Implantation. Acta Physics Polonica A 2017, 132: 264-269, DOI: 10.12693/APhysPolA.132.264
17. Grudzinski, W., Nierzwicki, L., Welc, R., Reszczynska, E., Luchowski, R., Czub, J., and Gruszecki, W.I. ; Localization and Orientation of Xanthophylls in a Lipid Bilayer. Scientific Reports 2017, 7: 9619, DOI: 10.1038/s41598-017-10183-7
18. Grudzinski, W., Piet, M., Luchowski, R., Reszczynska, E., Welc, R., Paduch, R., and Gruszecki, W.I. ; Different molecular organization of two carotenoids, lutein and zeaxanthin, in human colon epithelial cells and colon adenocarcinoma cells. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 2018, 188, 57–63.
19. Plazinska, A., Plazinski, W., Luchowski, R., Wnorowski, A., Grudzinski, W., and Gruszecki, W.I. ; Ligand-induced action of the W286(6.48) rotamer toggle switch in the beta(2)-adrenergic receptor. Phys. Chem. Chem. Phys. 2018, 20, 581–594.
20. Matwijczuk, A., Janik, E., Luchowski, R., Niewiadomy, A., Gruszecki, W.I. and Gagos, M.; Spectroscopic studies of the molecular organization of 4-([1,2,4] triazolo [4,3-a] pyridin-3-yl)-6-methylbenzene-1,3-diol in selected solvents. J. Luminesc. 2018, 194, 208–218.
21. Pawlikowska-Pawlega, B., Kapral, J., Gawron, A., Stochmal, A., Zuchowski, J., Pecio, L., Luchowski, R., Grudzinski, W., and Gruszecki, W.I.; Interaction of a quercetin derivative - lensoside Aβ with liposomal membranes. BBA - Biomembranes. 2018, 1860, 292–299.
22. Niewiadomska, E.; Brueckner, K.; Mulisch, M.; Kruk, J.; Orzechowska, A.; Pilarska, M.; Luchowski, R.; Gruszecki, W. I.; Krupinska, K. Lack of Tocopherols Influences the PSII Antenna and the Functioning of Photosystems under Low Light. J. Plant Physiol. 2018, 223, 57–64.
23. Tchorzewska, D.; Luchowski, R.; Gruszecki, W.; Winiarczyk, K. Comparative Studies of Live Tapetum Cells in Sterile Garlic (Allium Sativum) and Fertile Leek (Allium Ampeloprasum) Using the Fluorescence Lifetime Imaging Analytical Method. S. Afr. J. Bot. 2018, 117, 222–231.
24. Grela, E.; Wieczor, M.; Luchowski, R.; Zielinska, J.; Barzycka, A.; Grudzinski, W.; Nowak, K.; Tarkowski, P.; Czub, J.; Gruszecki, W. I. Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics. Mol. Pharm. 2018, 15 (9), 4202–4213.
25. Grela, E.; Piet, M.; Luchowski, R.; Grudzinski, W.; Paduch, R.; Gruszecki, W. I. Imaging of Human Cells Exposed to an Antifungal Antibiotic Amphotericin B Reveals the Mechanisms Associated with the Drug Toxicity and Cell Defence. Sci Rep 2018, 8, 14067
26. Zdybicka-Barabas, A.; Stączek, S.; Pawlikowska-Pawlęga, B.; Mak, P.; Luchowski, R.; Skrzypiec, K.; Mendyk, E.; Wydrych, J.; Gruszecki, W. I.; Cytryńska, M. Studies on the Interactions of Neutral Galleria Mellonella Cecropin D with Living Bacterial Cells. Amino Acids 2018.

27. Wu, A.; Grela, E.; Wojtowicz, K.; Filipczak, N.; Hamon, Y.; Luchowski, R.; Grudzinski, W.; Raducka-Jaszul, O.; Gagos, M.; Szczepaniak, A.; Chimini, G.; Gruszecki, W.; Trombik, T. ABCA1 Transporter Reduces Amphotericin B Cytotoxicity in Mammalian Cells. Cell. Mol. Life Sci. 2019, 76 (24), 4979–4994. https://doi.org/10.1007/s00018-019-03154-w.

28. Grela, E.; Zdybicka-Barabas, A.; Pawlikowska-Pawlega, B.; Cytrynska, M.; Wlodarczyk, M.; Grudzinski, W.; Luchowski, R.; Gruszecki, W. I. Modes of the Antibiotic Activity of Amphotericin B against Candida Albicans. Sci Rep 2019, 9, 17029. https://doi.org/10.1038/s41598-019-53517-3.

29. Turek, M.; Drozdziel, A.; Pyszniak, K.; Luchowski, R.; Grudzinski, W.; Klimek-Turek, A. Modification of PET Polymer Foil by Na+ Implantation. Acta Phys. Pol. A 2019, 136 (2), 278–284. https://doi.org/10.12693/APhysPolA.136.278.

30. Sek, A.; Welc, R.; Mendes-Pinto, M. M.; Reszczynska, E.; Grudzinski, W.; Luchowski, R.; Gruszecki, W. Raman Spectroscopy Analysis of Molecular Configuration Forms of the Macular Xanthophylls. J. Raman Spectrosc. https://doi.org/10.1002/jrs.5818.

31. Palusinska-Szysz, M.; Luchowski, R.; Gruszecki, W.; Choma, A.; Szuster-Ciesielska, A.; Lueck, C.; Petzold, M.; Sroka-Bartnicka, A.; Kowalczyk, B. The Role of Legionella Pneumophila Serogroup 1 Lipopolysaccharide in Host-Pathogen Interaction. Front. Microbiol. 2019, 10, 2890. https://doi.org/10.3389/fmicb.2019.02890.

32. Luchowski, R.; Grudzinski, W.; Welc, R.; Mendes Pinto, M. M.; Sek, A.; Ostrowski, J.; Nierzwicki, L.; Chodnicki, P.; Wieczor, M.; Sowinski, K.; Rejdak, R.; Juenemann, A. G. M.; Teresinski, G.; Czub, J.; Gruszecki, W. I. Light-Modulated Sunscreen Mechanism in the Retina of the Human Eye. J. Phys. Chem. B 2021, 125 (23), 6090–6102. https://doi.org/10.1021/acs.jpcb.1c01198.

33. Maciejczyk, A.; Kapral-Piotrowska, J.; Sumorek-Wiadro, J.; Zając, A.; Grela, E.; Luchowski, R.; Gruszecki, W. I.; Lemieszek, M. K.; Wertel, I.; Pecio, Ł.; Żuchowski, J.; Skalicka-Woźniak, K.; Pawlikowska-Pawlęga, B.; Hułas-Stasiak, M.; Rzeski, W.; Rola, R.; Jakubowicz-Gil, J. Lensoside Aβ as an Adjuvant to the Anti-Glioma Potential of Sorafenib. Cancers 2021, 13 (11), 2637. https://doi.org/10.3390/cancers13112637.

34. Welc, R.; Luchowski, R.; Kluczyk, D.; Zubik-Duda, M.; Grudzinski, W.; Maksim, M.; Reszczynska, E.; Sowinski, K.; Mazur, R.; Nosalewicz, A.; Gruszecki, W. I. Mechanisms Shaping the Synergism of Zeaxanthin and PsbS in Photoprotective Energy Dissipation in the Photosynthetic Apparatus of Plants. Plant J. 2021, 107 (2), 418–433. https://doi.org/10.1111/tpj.15297.

35. Zielinska, J.; Wieczor, M.; Chodnicki, P.; Grela, E.; Luchowski, R.; Nierzwicki, L.; Baczek, T.; Gruszecki, W. I.; Czub, J. Self-Assembly, Stability and Conductance of Amphotericin B Channels: Bridging the Gap between Structure and Function. Nanoscale 2021, 13 (6), 3686–3697. https://doi.org/10.1039/d0nr07707k.

36. Zubik, M.; Luchowski, R.; Kluczyk, D.; Grudzinski, W.; Maksim, M.; Nosalewicz, A.; Gruszecki, W. Recycling of Energy Dissipated as Heat Accounts for High Activity of Photosystem II. J. Phys. Chem. Lett. 2020, 11 (9), 3242–3248. https://doi.org/10.1021/acs.jpclett.0c00486.

37. Palusinska-Szysz, M.; Zdybicka-Barabas, A.; Luchowski, R.; Reszczynska, E.; Smialek, J.; Mak, P.; Gruszecki, W.; Cytrynska, M. Choline Supplementation SensitizesLegionella DumoffiitoGalleria MellonellaApolipophorin III. Int. J. Mol. Sci. 2020, 21 (16), 5818. https://doi.org/10.3390/ijms21165818.

38. Sek, A.; Welc, R.; Mendes-Pinto, M. M.; Reszczynska, E.; Grudzinski, W.; Luchowski, R.; Gruszecki, W. Raman Spectroscopy Analysis of Molecular Configuration Forms of the Macular Xanthophylls. J. Raman Spectrosc. 2020, 51 (4), 635–641. https://doi.org/10.1002/jrs.5818.